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Physical exercise has established efficacy as an in individuals with depression and current medical evidence supports the use of exercise as both a against and an adjunct therapy with antidepressant medication for depressive disorders. A July 2016 concluded that physical exercise improves overall quality of life in individuals with depression relative to controls. One systematic review noted that may be effective in alleviating symptoms of . The biomolecular basis for exercise-induced antidepressant effects is believed to be a result of increased signaling, particularly .